102 citations · 272 across the 17 of their papers we have counts for
17 papers
A seven-step guide to spatial, agent-based modelling of tumour evolution
Blair Colyer, Maciej Bak, David Basanta +1
Spatial agent-based models are increasingly used to investigate the evolution of solid tumours subject to localised cell-cell interactions and microenvironmental heterogeneity. Her…
A survey of open questions in adaptive therapy: bridging mathematics and clinical translation
Jeffrey West, Fred Adler, Jill Gallaher +9
Adaptive therapy is a dynamic cancer treatment protocol that updates (or "adapts") treatment decisions in anticipation of evolving tumor dynamics. This broad term encompasses many…
Bifurcation Mechanism Design -- From Optimal Flat Taxes to Improved Cancer Treatments
Ger Yang, Georgios Piliouras, David Basanta
Small changes to the parameters of a system can lead to abrupt qualitative changes of its behavior, a phenomenon known as bifurcation. Such instabilities are typically considered p…
Simulated Ablation for Detection of Cells Impacting Paracrine Signalling in Histology Analysis
Jake P. Taylor-King, Etienne Baratchart, Andrew Dhawan +6
Intra-tumour phenotypic heterogeneity limits accuracy of clinical diagnostics and hampers the efficiency of anti-cancer therapies. Dealing with this cellular heterogeneity requires…
A Mean-Field Approach to Evolving Spatial Networks, with an Application to Osteocyte Network Formation
Jake P. Taylor-King, David Basanta, S. Jonathan Chapman +1
We consider evolving networks in which each node can have various associated properties (a state) in addition to those that arise from network structure. For example, each node can…
Cancer treatment scheduling and dynamic heterogeneity in social dilemmas of tumour acidity and vasculature
Artem Kaznatcheev, Robert Vander Velde, Jacob G. Scott +1
Background: Tumours are diverse ecosystems with persistent heterogeneity in various cancer hallmarks like self-sufficiency of growth factor production for angiogenesis and reprogra…