106 citations · 291 across the 10 of their papers we have counts for
4 papers · 1 filter
Cells exploit a phase transition to mechanically remodel the fibrous extracellular matrix
Georgios Grekas, Maria Proestaki, Phoebus Rosakis +3
Through mechanical forces, biological cells remodel the surrounding collagen network, generating striking deformation patterns. Tethers-tracts of high densification and fiber align…
A Minimal Mechanosensing Model Predicts Keratocyte Evolution on Flexible Substrates
Zhiwen Zhang, Phoebus Rosakis, Thomas Y. Hou +1
A mathematical model is proposed for shape evolution and locomotion of fish epidermal keratocytes on elastic substrates. The model is based on mechanosensing concepts: cells apply…
A Model for Compression-Weakening Materials and the Elastic Fields due to Contractile Cells
Phoebus Rosakis, Jacob Notbohm, Guruswami Ravichandran
We construct a homogeneous, nonlinear elastic constitutive law, that models aspects of the mechanical behavior of inhomogeneous fibrin networks. Fibers in such networks buckle when…
Microbuckling of Fibrin Provides a Mechanism for Cell Mechanosensing
Jacob Notbohm, Ayelet Lesman, Phoebus Rosakis +2
Biological cells sense and respond to mechanical forces, but how such a mechanosensing proccess takes place in a nonlinear inhomogeneous fibrous matrix remains unknown. We show tha…