2 papers
cs.LG2026
ConTact: Contact-First Antibody CDR Design via Explicit Interface Reasoning
Mansoor Ahmed, Spencer VonBank, Nadeem Taj +3
Computational antibody CDR design methods condition on antigen structure to generate binding loops. Yet, the existing architectures conflate two fundamentally distinct sub-problems…
cs.LG2026
EvoStruct: Bridging Evolutionary and Structural Priors for Antibody CDR Design via Protein Language Model Adaptation
Mansoor Ahmed, Sujin Lee, Umar Khayaz +1
Equivariant graph neural network (GNN) methods for antibody complementarity-determining region (CDR) design achieve the highest sequence recovery but suffer from severe vocabulary…