137 citations · 404 across the 17 of their papers we have counts for
4 papers · 1 filter
Mapping high-growth phenotypes in the flux space of microbial metabolism
Oriol Güell, Francesco Alessandro Massucci, Francesc Font-Clos +2
Experimental and empirical observations on cell metabolism cannot be understood as a whole without their integration into a consistent systematic framework. However, the characteri…
Energy metabolism and glutamate-glutamine cycle in the brain: a stoichiometric modeling perspective
Francesco Alessandro Massucci, Mauro DiNuzzo, Federico Giove +4
The energetics of cerebral activity critically relies on the functional and metabolic interactions between neurons and astrocytes. Important open questions include the relation bet…
A Novel Methodology to Estimate Metabolic Flux Distributions in Constraint-Based Models
Francesco Alessandro Massucci, Francesc Font-Clos, Andrea De Martino +1
Quite generally, constraint-based metabolic flux analysis describes the space of viable flux configurations for a metabolic network as a high-dimensional polytope defined by the li…
On the role of conserved moieties in shaping the robustness and production capabilities of reaction networks
Andrea De Martino, Carlotta Martelli, Francesco A. Massucci
We study a simplified, solvable model of a fully-connected metabolic network with constrained quenched disorder to mimic the conservation laws imposed by stoichiometry on chemical…