302 citations · 1.2k across the 30 of their papers we have counts for
8 papers · 1 filter
Quantized Dehydration and the Determinants of Selectivity in the NaChBac Bacterial Sodium Channel
O. A. Fedorenko, I. Kh. Kaufman, W. A. T. Gibby +3
A discrete electrostatic/diffusion model has been developed to describe the selective permeation of ion channels, based on ionic Coulomb blockade (ICB) and quantised dehydration (Q…
Effect of Local Binding on Stochastic Transport in Ion Channels
I. Kh. Kaufman, W. A. T. Gibby, D. G. Luchinsky +1
Ionic Coulomb blockade (ICB) is an electrostatic phenomenon recently discovered in low-capacitance ion channels/nanopores. Depending on the fixed charge that is present, ICB strong…
Kinetic model of selectivity and conductivity of the KcsA filter
W. A. T. Gibby, D. G. Luchinsky, I. Kh. Kaufman A. Ward +1
We introduce a self-consistent multi-species kinetic theory based on the structure of the narrow voltage-gated potassium channel. Transition rates depend on a complete energy spect…
Statistical Theory of Selectivity and Conductivity in Biological Channels
D. G. Luchinsky, W. A. T. Gibby, I. Kaufman +2
We present an equilibrium statistical-mechanical theory of selectivity in biological ion channels. In doing so, we introduce a grand canonical ensemble for ions in a channel's sele…
Dynamics of ions in the selectivity filter of the KcsA channel: Towards a coupled Brownian particle description
Salvatore M. Cosseddu, Igor A. Khovanov, Michael P. Allen +3
The statistical and dynamical properties of ions in the selectivity filter of the KcsA ion channel are considered on the basis of molecular dynamics (MD) simulations of the KcsA pr…
Energetics of discrete selectivity bands and mutation-induced transitions in the calcium-sodium ion channels family
I. Kaufman, D. G. Luchinsky, R. Tindjong +2
We use Brownian dynamics simulations to study the permeation properties of a generic electrostatic model of a biological ion channel as a function of the fixed charge at its…
Multi-ion conduction bands in a simple model of calcium ion channels
I. Kaufman, D. G. Luchinsky, R. Tindjong +2
We report self-consistent Brownian dynamics simulations of a simple electrostatic model of the selectivity filters (SF) of calcium ion channels. They reveal regular structure in th…
Ionic channels as electrostatic amplifiers of charge fluctuations
D. G. Luchinsky, R. Tindjong, I. Kaufman +2
Electrostatic interaction between ions in an ionic channel and the charge fluctuations in the channel mouth are considered. It is shown that the charge fluctuations can be enhanced…