3 citations · 3 across the 2 of their papers we have counts for
5 papers
Oxygenation and spatial heterogeneity shape radiotherapy protocol ranking through phenotypic adaptation
Francesco Albanese, Giulia Chiari, Marcello Edoardo Delitala
Tumor response to radiotherapy is strongly influenced by oxygen availability and phenotypic heterogeneity, yet their combined impact on the relative performance of fractionation sc…
A hybrid discrete-continuum modelling approach for the interactions of the immune system with oncolytic viral infections
David Morselli, Marcello E. Delitala, Adrianne L. Jenner +1
Oncolytic virotherapy, utilizing genetically modified viruses to combat cancer and trigger anti-cancer immune responses, has garnered significant attention in recent years. In our…
The role of viral dynamics and infectivity in models of oncolytic virotherapy for tumours with different motility
David Morselli, Federico Frascoli, Marcello Edoardo Delitala
The use of ad-hoc engineered viruses in the fight against tumours is one of the greatest ideas in cancer therapeutics within the last three decades. Together with other strategies…
Multi-scale modeling of Snail-mediated response to hypoxia in tumor progression
Giulia Chiari, Martina Conte, Marcello Delitala
Tumor cell migration within the microenvironment is a crucial aspect for cancer progression and, in this context, hypoxia has a significant role. An inadequate oxygen supply acts a…
A phenotype-structured mathematical model for the influence of hypoxia on oncolytic virotherapy
David Morselli, Giulia Chiari, Federico Frascoli +1
The effectiveness of oncolytic virotherapy is significantly affected by several elements of the tumour microenvironment, which reduce the ability of the virus to infect cancer cell…