4 papers
Boundedness of solutions in feedback systems with antithetic controllers
Moh Kamalul Wafi, Arthur C. B. de Oliveira, Eduardo D. Sontag
Antithetic feedback controllers have become a key experimental and theoretical tool in synthetic biology. Introduced by Khammash and collaborators about 10 years ago, they are empl…
Learning Genetic Circuit Modules with Neural Networks: Full Version
Jichi Wang, Eduardo D. Sontag, Domitilla Del Vecchio
In several applications, including in synthetic biology, one often has input/output data on a system composed of many modules, and although the modules' input/output functions and…
Interplay between Contractivity and Monotonicity for Reaction Networks
Alon Duvall, M. Ali Al-Radhawi, Dhruv D. Jatkar +1
We establish a new relationship between monotonicity and contractivity and use this connection to describe a new general class of weakly contractive reaction networks. The new clas…
Competition for binding targets results in paradoxical effects for simultaneous activator and repressor action -- Extended Version
M. Ali Al-Radhawi, Krishna Manoj, Dhruv D. Jatkar +3
In the context of epigenetic transformations in cancer metastasis, a puzzling effect was recently discovered, in which the elimination (knock-out) of an activating regulatory eleme…