activity
20222026
most citedEpigenetic factor competition reshapes the EMT landscape

28 citations · 32 across the 16 of their papers we have counts for

collaborators

16 papers

eess.SY2026

Smooth globally PLI functions are nonlinear least-squares, and so are their gradient-dominated cousins

Eduardo D. Sontag

Boumal, Criscitiello and Rebjock (BCR) proved that if is a contractible, connected and complete Riemannian manifold, then every smooth function satisfying the…

eess.SY2026

On input-output persistency and the interconnection of positive nonlinear systems

Arthut Castello B. de Oliveira, Moh K. Wafi, Eduardo D. Sontag

In this paper we study feedback interconnections of positive nonlinear SISO systems and introduce two complementary properties: persistent-input/persistent-output (PIPO) for the pl…

cs.LG2025

Autoencoding Dynamics: Topological Limitations and Capabilities

Matthew D. Kvalheim, Eduardo D. Sontag

Given a "data manifold" and "latent space" , an autoencoder is a pair of continuous maps consisting of an "encoder" $E\colon \mathbb{R}^n\t…

math.OC2025

On the (almost) Global Exponential Convergence of the Overparameterized Policy Optimization for the LQR Problem

Moh Kamalul Wafi, Arthur Castello B. de Oliveira, Eduardo D. Sontag

In this work we study the convergence of gradient methods for nonconvex optimization problems -- specifically the effect of the problem formulation to the convergence behavior of t…

eess.SY2025

Small-Covariance Noise-to-State Stability of Stochastic Systems and Its Applications to Stochastic Gradient Dynamics

Leilei Cui, Zhong-Ping Jiang, Eduardo D. Sontag

This paper studies gradient dynamics subject to additive random noise, which may arise from sources such as stochastic gradient estimation, measurement noise, or stochastic samplin…

cs.LG2025

Some remarks on gradient dominance and LQR policy optimization

Eduardo D. Sontag

Solutions of optimization problems, including policy optimization in reinforcement learning, typically rely upon some variant of gradient descent. There has been much recent work i…

math.OC2025

Perturbed Gradient Descent Algorithms are Small-Disturbance Input-to-State Stable

Leilei Cui, Zhong-Ping Jiang, Eduardo D. Sontag +1

This article investigates the robustness of gradient descent algorithms under perturbations. The concept of small-disturbance input-to-state stability (ISS) for discrete-time nonli…

math.OC2025

Universal Formulas for Safe Control and Their Neural Network Approximations

Pol Mestres, Jorge Cortés, Eduardo D. Sontag

We study the problem of designing a controller that satisfies an arbitrary number of affine inequalities at every point in the state space. This is motivated by the fact that a var…

math.OC2025

Remarks on the Polyak-Lojasiewicz inequality and the convergence of gradient systems

Arthur Castello B. de Oliveira, Leilei Cui, Eduardo D. Sontag

This work explores generalizations of the Polyak-Lojasiewicz inequality (PLI) and their implications for the convergence behavior of gradient flows in optimization problems. Motiva…

math.DS2025

Global linearization of asymptotically stable systems without hyperbolicity

Matthew D. Kvalheim, Eduardo D. Sontag

We give a proof of an extension of the Hartman-Grobman theorem to nonhyperbolic but asymptotically stable equilibria of vector fields. Moreover, the linearizing topological conjuga…

eess.SY2024★ 2 cited

Convergence Analysis of Gradient Flow for Overparameterized LQR Formulations

Arthur Castello B. de Oliveira, Milad Siami, Eduardo D. Sontag

Motivated by the growing use of artificial intelligence (AI) tools in control design, this paper analyses the intersection between results from gradient methods for the model-free…

eess.SY2024

Regularizing Numerical Extremals Along Singular Arcs: A Lie-Theoretic Approach

Arthur Castello Branco de Oliveira, Milad Siami, Eduardo D. Sontag

Numerical ``direct'' approaches to time-optimal control often fail to find solutions that are singular in the sense of the Pontryagin Maximum Principle, performing better when sear…

eess.SY2023★ 2 cited

Properties of Immersions for Systems with Multiple Limit Sets with Implications to Learning Koopman Embeddings

Zexiang Liu, Necmiye Ozay, Eduardo D. Sontag

Linear immersions (such as Koopman eigenfunctions) of a nonlinear system have wide applications in prediction and control. In this work, we study the properties of linear immersion…

math.OC2023

Small-Disturbance Input-to-State Stability of Perturbed Gradient Flows: Applications to LQR Problem

Leilei Cui, Zhong-Ping Jiang, Eduardo D. Sontag

This paper studies the effect of perturbations on the gradient flow of a general nonlinear programming problem, where the perturbation may arise from inaccurate gradient estimation…

cs.LG2023

Why should autoencoders work?

Matthew D. Kvalheim, Eduardo D. Sontag

Deep neural network autoencoders are routinely used computationally for model reduction. They allow recognizing the intrinsic dimension of data that lie in a -dimensional subset…

q-bio.MN2022★ 28 cited

Epigenetic factor competition reshapes the EMT landscape

M. Ali Al-Radhawi, Shubham Tripathi, Yun Zhang +2

The emergence of and transitions between distinct phenotypes in isogenic cells can be attributed to the intricate interplay of epigenetic marks, external signals, and gene regulato…