35 citations · 64 across the 4 of their papers we have counts for
3 papers · 1 filter
The Trial within Cohorts (TwiCs) study design in oncology: Experience and methodological reflections
Rob Kessels, Anne M. May, Miriam Koopman +1
A Trial within Cohorts (TwiCs) study design is a trial design that uses the infrastructure of an observational cohort study to initiate a randomized trial. Upon cohort enrollment,…
Correction of overfitting bias in regression models
Emanuele Massa, Marianne Jonker, Kit Roes +1
Regression analysis based on many covariates is becoming increasingly common. However, when the number of covariates is of the same order as the number of observations , max…
Combining Evidence from Clinical Trials in Conditional or Accelerated Approval
Manja Deforth, Charlotte Micheloud, Kit C Roes +1
Conditional (European Medicines Agency) or accelerated (U.S. Food and Drug Administration) approval of drugs allow earlier access to promising new treatments that address unmet med…