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stat.ME2025
The role of post intercurrent event data in the estimation of hypothetical estimands in clinical trials
Jonathan W. Bartlett, Rhian M. Daniel
Estimation of hypothetical estimands in clinical trials typically does not make use of data that may be collected after the intercurrent event (ICE). Some recent papers have shown…
stat.ME2025
Dealing with multiple intercurrent events using hypothetical and treatment policy strategies simultaneously
Camila Olarte Parra, Rhian M. Daniel, Jonathan W. Bartlett
To precisely define the treatment effect of interest in a clinical trial, the ICH E9 estimand addendum describes that relevant so-called intercurrent events should be identified an…