most citedAn Integrated Biological Optimization framework for proton SBRT FLASH treatment planning allows dose, dose rate, and LET optimization using patient-specific ridge filters

54 citations · 93 across the 5 of their papers we have counts for

collaborators

5 papers

physics.med-ph2023

A novel inverse algorithm to solve IPO-IMPT of proton FLASH therapy with sparse filters

Nathan Harrison, Minglei Kang, Ruirui Liu +9

Purpose:The recently proposed IPO-IMPT framework allows simultaneous optimization of dose, dose rate, and LET for FLASH treatment planning. Finding solutions to IPO-IMPT is difficu…

physics.med-ph2022★ 1 cited

Development of a Full Monte Carlo Therapeutic Dose Calculation Toolkit for Halcyon Using Geant4

Ruirui Liu, Zhen Ji, Xiandong Zhao +4

Purpose: To develop a Monte Carlo (MC) therapeutic dose calculation toolkit of a recently released ring gantry linac in Geant4 (Version 10.7) for secondary dose validation of radio…

physics.med-ph2022★ 21 cited

Feasibility Study of Hybrid Inverse Planning with Transmission Beams and Single-energy Spread-out Bragg Peaks for Proton Flash Radiotherapy

Chaoqiong Ma, Xiaofeng Yang, Chih-Wei Chang +6

Ultra-high dose rate (FLASH) proton planning with only transmission beams (TBs) has limitations in normal tissue sparing. The single-energy spread-out Bragg peaks (SESOBPs) of FLAS…

physics.med-ph2022★ 17 cited

Measurement of the time structure of FLASH beams using prompt gamma rays and secondary neutrons as surrogates

Serdar Charyyev, Ruirui Liu, Xiaofeng Yang +5

We aim to investigate the feasibility of online monitoring of irradiation time (IRT) and scan time for FLASH radiotherapy using a pixelated semiconductor detector. Measurements of…

physics.med-ph2022★ 54 cited

An Integrated Biological Optimization framework for proton SBRT FLASH treatment planning allows dose, dose rate, and LET optimization using patient-specific ridge filters

Ruirui Liu, Serdar Charyyev, Niklas Wahl +10

Purpose: Patient-specific ridge filters can modulate proton energy to obtain a conformal dose. We describe a new framework for optimization of filter design and spot maps to meet t…