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q-bio.MN2025
Computational Drug Repurposing for Alzheimer's Disease via Sheaf Theoretic Population-Scale Analysis of snRNA-seq Data
Sean Cottrell, Seungmin Yoon, Xiaoqi Wei +2
Single-cell and single-nucleus RNA sequencing (scRNA-seq /snRNA-seq) are widely used to reveal heterogeneity in cells, showing a growing potential for precision and personalized me…
q-bio.BM2025
Persistent Sheaf Laplacian Analysis of Protein Flexibility
Nicole Hayes, Xiaoqi Wei, Hongsong Feng +2
Protein flexibility, measured by the B-factor or Debye-Waller factor, is essential for protein functions such as structural support, enzyme activity, cellular communication, and mo…