5 papers · 1 filter
Mixed genetic background better recapitulates developmental and psychiatric phenotypes and heterogeneity than inbred C57BL/6J mice
Ana Dudas, Ana Novak, Caroline Gora +4
Preclinical models of neurodevelopmental and psychiatric conditions often rely on inbred mouse strains like C57BL/6J (B6), which exhibit limited genetic and behavioral variability.…
The insertion of Neomycin cassette impairs maternal and social behaviors in Arc/Arg3.1 knock-out mice
Ana Dudas, Emilia Caire, Abdurahman Hassan a Kuku +14
The Neomycin resistance cassette (Neo+) is commonly inserted in the genome of mice to generate knock-out (KO) models. The effect of gene deletion on social behaviors in mice is con…
Deciphering autism heterogeneity: a molecular stratification approach in four mouse models
Caroline Gora, Ana Dudas, Océane Vaugrente +4
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by impairments in social interaction, communication, as well as restrained or stereotyped beh…
Effect of the social environment on olfaction and social skills in WT and mouse model of autism
Caroline Gora, Ana Dudas, Lucas Court +13
Autism spectrum disorders are complex, polygenic and heterogenous neurodevelopmental conditions, imposing a substantial economic burden. Genetics are influenced by the environment,…
Towards the convergent therapeutic potential of GPCRs in autism spectrum disorders
Anil Annamneedi, Caroline Gora, Ana Dudas +4
Changes in genetic and/or environmental factors to developing neural circuits and subsequent synaptic functions are known to be a causative underlying the varied socio-emotional be…