3 papers
math.DS2026
Mathematical models for CAR T immunotherapy and CD19 dynamics in leukemia: a comparative analysis
Salvador Chulián, Ana Niño-López, Rocío Picón-González +1
Chimeric Antigen Receptor (CAR) T cell therapy has emerged as a successful treatment for relapsed or refractory hematological malignancies, particularly for B cell Acute Lymphoblas…
math.GN2026
A Systematic Framework for Evaluating Topological Representations in Single-Cell Classification
Rocío Picón-González, Salvador Chulián, Ana Niño-López +2
Recent advances in biomedicine generate high-dimensional single-cell data that describe cellular heterogeneity with unprecedented detail, but their geometric complexity and non-lin…
math.DS2022
Mathematical Modeling of Leukemia Chemotherapy in Bone Marrow
Ana Niño-López, Salvador Chulián, Álvaro Martínez-Rubio +2
Acute Lymphoblastic Leukemia (ALL) accounts for the 80% of leukemias when coming down to pediatric ages. Survival of these patients has increased by a considerable amount in recent…