3 papers
stat.ME2026
Standardized Dynamic Borrowing: Uniform Control of Information Borrowing
Huan Wang, Fei Wu, Yeh-Fong Chen
Dynamic borrowing can improve efficiency in clinical trials using external information, but existing methods may not offer transparent, prespecified control over borrowing. We intr…
stat.ME2024
A comparison of methods for estimating the average treatment effect on the treated for externally controlled trials
Huan Wang, Fei Wu, Yeh-Fong Chen
While randomized trials may be the gold standard for evaluating the effectiveness of the treatment intervention, in some special circumstances, single-arm clinical trials utilizing…
stat.ME2022
Utilizing Win Ratio Approaches and Two-Stage Enrichment Designs for Small-Sized Clinical Trials
Jialu Wang, Yeh-Fong Chen, Thomas Gwise
Conventional methods for analyzing composite endpoints in clinical trials often only focus on the time to the first occurrence of all events in the composite. Therefore, they have…