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stat.ME2023
The use of restricted mean survival time to estimate treatment effect under model misspecification, a simulation study
Emily Alger, David S. Robertson, Abigail J. Burdon
The use of the non-parametric Restricted Mean Survival Time endpoint (RMST) has grown in popularity as trialists look to analyse time-to-event outcomes without the restrictions of…
stat.ME2023
Adaptive enrichment trial designs using joint modeling of longitudinal and time-to-event data
Abigail J. Burdon, Richard D. Baird, Thomas Jaki
Adaptive enrichment allows for pre-defined patient subgroups of interest to be investigated throughout the course of a clinical trial. Many trials which measure a long-term time-to…