4 papers · 1 filter
Trial design considerations in the face of overdispersion and time-varying event rates: a meta-regression approach with an application in asthma
Bohua Chen, Christian Röver, Stefan Andreas +2
**Purpose:** Relative changes in event rates are a common primary endpoint in confirmatory asthma trials. Reliable assumptions about baseline event rates and extra-Poisson variabil…
Discussion on "Principled type I error rate inflation in two-arm clinical trial designs with external control information borrowing" by Silvia Calderazzo, Manuel Wiesenfarth, Vivienn Weru, and Annette Kopp-Schneider
Tim Friede, Christian Röver
Consideration of frequentist type-I error or power based on certain fixed conditions may not fully embrace the aims of a Bayesian analysis; this is particularly true in settings wh…
Empirical prior distributions for treatment-by-subgroup interaction heterogeneity in random-effects meta-analysis
Renato Panaro, Christian Röver, Tim Friede
Subgroup analyses are central to the assessment of benefits and risks, where recommendations may depend on evidence that treatment effects differ across patient groups. Valid subgr…
Including historical control data in simultaneous inference for pre-clinical multi-arm studies
Max Menssen, Carsten Kneuer, Gyamfi Akyianu +3
In pre- and non-clinical toxicology, the reduction of animal use is highly desireable. Although approaches for possible sample size reduction in the concurrent control group were s…