108 citations · 171 across the 4 of their papers we have counts for
4 papers
Identifying mechanisms driving the early response of triple negative breast cancer patients to neoadjuvant chemotherapy using a mechanistic model integrating in vitro and in vivo imaging data
Guillermo Lorenzo, Angela M. Jarrett, Christian T. Meyer +3
Neoadjuvant chemotherapy (NAC) is a standard-of-care treatment for locally advanced triple negative breast cancer (TNBC) before surgery. The early assessment of TNBC response to NA…
An unbiased metric of antiproliferative drug effect in vitro
Leonard A. Harris, Peter L. Frick, Shawn P. Garbett +5
In vitro cell proliferation assays are widely used in pharmacology, molecular biology, and drug discovery. Using theoretical modeling and experimentation, we show that current anti…
The contribution of age structure to cell population responses to targeted therapeutics
Pierre Gabriel, Shawn P. Garbett, Vito Quaranta +2
Cells grown in culture act as a model system for analyzing the effects of anticancer compounds, which may affect cell behavior in a cell cycle position-dependent manner. Cell synch…
A Spatial Model of Tumor-Host Interaction: Application of Chemotherapy
Peter Hinow, Philip Gerlee, Lisa J. McCawley +9
In this paper we consider chemotherapy in a spatial model of tumor growth. The model, which is of reaction-diffusion type, takes into account the complex interactions between the t…