4 papers
Why decision curves go above or below treat-all and treat-none: a PPV- and calibration-based guide for clinical prediction models
Linard Hoessly
Net benefit is widely used to assess whether clinical prediction models can improve decision-making, but its interpretation is often difficult in practice. In this didactic note, w…
Identifiability of SDEs for reaction networks
Louis Faul, Linard Hoessly, Panqiu Xia
Biochemical reaction networks are widely applied across scientific disciplines to model complex dynamic systems. We investigate the diffusion approximation of reaction networks wit…
Reaction cleaving and complex-balanced distributions for chemical reaction networks with general kinetics
Linard Hoessly, Carsten Wiuf, Panqiu Xia
Reaction networks have become a major modelling framework in the biological sciences from epidemiology and population biology to genetics and cellular biology. In recent years, muc…
Impossibility results for equating the Youden Index with average scoring rules and Tjur -like metrics
Linard Hoessly
We consider the Youden index fas well as measures evaluating predicted probabilities for the maximum-likelihood estimate of a logistic regression model with predictor the classifie…