3 papers
stat.AP2025
Detecting gene-environment interactions to guide personalized intervention: boosting distributional regression for polygenic scores
Qiong Wu, Hannah Klinkhammer, Kiran Kunwar +3
Polygenic risk scores can be used to model the individual genetic liability for human traits. Current methods primarily focus on modeling the mean of a phenotype neglecting the var…
q-bio.QM2023
Redundancy-aware unsupervised rankings for collections of gene sets
Chiara Balestra, Carlo Maj, Emmanuel Müller +1
The biological roles of gene sets are used to group them into collections. These collections are often characterized by being high-dimensional, overlapping, and redundant families…
q-bio.GN2022
Redundancy-aware unsupervised ranking based on game theory -- application to gene enrichment analysis
Chiara Balestra, Carlo Maj, Emmanuel Mueller +1
Gene set collections are a common ground to study the enrichment of genes for specific phenotypic traits. Gene set enrichment analysis aims to identify genes that are over-represen…