2 papers
q-bio.PE2024
Joint identifiability of ancestral sequence, phylogeny and mutation rates under the TKF91 model
Alex Xue, Brandon Legried, Wai-Tong Louis Fan
We consider the problem of identifying jointly the ancestral sequence, the phylogeny and the parameters in models of DNA sequence evolution with insertion and deletion (indel). Und…
q-bio.PE2022
Pairwise sequence alignment at arbitrarily large evolutionary distance
Brandon Legried, Sebastien Roch
Ancestral sequence reconstruction is a key task in computational biology. It consists in inferring a molecular sequence at an ancestral species of a known phylogeny, given descenda…