3 papers
stat.ME2024
Using shrinkage methods to estimate treatment effects in overlapping subgroups in randomized clinical trials with a time-to-event endpoint
Marcel Wolbers, Mar Vázquez Rabuñal, Ke Li +2
In randomized controlled trials, forest plots are frequently used to investigate the homogeneity of treatment effect estimates in subgroups. However, the interpretation of subgroup…
stat.AP2024
Survival analysis for AdVerse events with VarYing follow-up times (SAVVY): summary of findings and a roadmap for the future of safety analyses in clinical trials
Kaspar Rufibach, Jan Beyersmann, Tim Friede +2
The SAVVY project aims to improve the analyses of adverse events (AEs) in clinical trials through the use of survival techniques appropriately dealing with varying follow-up times…
stat.ME2022
Applying the Estimand and Target Trial frameworks to external control analyses using observational data: a case study in the solid tumor setting
Letizia Polito, Qixing Liang, Navdeep Pal +5
In causal inference, the correct formulation of the scientific question of interest is a crucial step. Here we apply the estimand framework to a comparison of the outcomes of patie…