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physics.optics2025

Structured Random Models for Phase Retrieval with Optical Diffusers

Zhiyuan Hu, Fakhriyya Mammadova, Julián Tachella +2

Phase retrieval is a nonlinear inverse problem that arises in a wide range of imaging modalities, from electron microscopy to Fourier ptychography. In particular, the reconstructio…

physics.optics2025

A global inverse-problem approach to quantitative photo-switching optoacoustic mesoscopy

Yan Liu, Jonathan Chuah, Michael Unser +1

In this paper, we propose a global framework that includes a detailed model of the photo-switching and acoustic processes for photo-switching optoacoustic mesoscopy, based on the u…

physics.optics2025

Revisiting PSF models: unifying framework and high-performance implementation

Yan Liu, Vasiliki Stergiopoulou, Jonathan Chuah +5

Localization microscopy often relies on detailed models of point spread functions. For applications such as deconvolution or PSF engineering, accurate models for light propagation…

physics.optics2025

Perturbative Fourier Ptychographic Microscopy for Fast Quantitative Phase Imaging

Martin Zach, Kuan-Chen Shen, Ruiming Cao +3

In computational phase imaging with a microscope equipped with an array of light emitting diodes as illumination unit, conventional Fourier ptychographic microscopy achieves high r…

physics.optics2025

Model-based temporal unmixing towards quantitative photo-switching optoacoustic tomography

Yan Liu, Jonathan Chuah, Yishu Huang +3

Optoacoustic (OA) imaging combined with reversibly photoswitchable proteins has emerged as a promising technology for the high-sensitivity and multiplexed imaging of cells in live…

physics.optics2024

Point-Spread-Function Engineering in MINFLUX: Optimality of Donut and Half-Moon Excitation Patterns

Yan Liu, Jonathan Dong, Juan Augusto Maya +2

Localization microscopy enables imaging with resolutions that surpass the conventional optical diffraction limit. Notably, the MINFLUX method achieves super-resolution by shaping t…