10 papers
Histopathology Multi-modal Embedding for Pathology Composed Retrieval
Qifeng Zhou, Wenliang Zhong, Thao M. Dang +4
To overcome the black-box nature of predictive AI and the hallucination risks of generative models, retrieval-based models offer an interpretable, evidence-based paradigm for patho…
scpFormer: A Foundation Model for Unified Representation and Integration of the Single-Cell Proteomics
Qifeng Zhou, Lei Yu, Yuzhi Guo +5
The integration of single-cell proteomic data is often hindered by the fragmented nature of targeted antibody panels. To address this limitation, we introduce scpFormer, a transfor…
TRIDENT: Tri-Modal Molecular Representation Learning with Taxonomic Annotations and Local Correspondence
Feng Jiang, Mangal Prakash, Hehuan Ma +6
Molecular property prediction aims to learn representations that map chemical structures to functional properties. While multimodal learning has emerged as a powerful paradigm to l…
GenePheno: Interpretable Gene Knockout-Induced Phenotype Abnormality Prediction from Gene Sequences
Jingquan Yan, Yuwei Miao, Lei Yu +4
Exploring how genetic sequences shape phenotypes is a fundamental challenge in biology and a key step toward scalable, hypothesis-driven experimentation. The task is complicated by…
GRAM-DTI: adaptive multimodal representation learning for drug target interaction prediction
Feng Jiang, Amina Mollaysa, Hehuan Ma +4
Drug target interaction (DTI) prediction is a cornerstone of computational drug discovery, enabling rational design, repurposing, and mechanistic insights. While deep learning has…
Text-Guided Multi-Instance Learning for Scoliosis Screening via Gait Video Analysis
Haiqing Li, Yuzhi Guo, Feng Jiang +5
Early-stage scoliosis is often difficult to detect, particularly in adolescents, where delayed diagnosis can lead to serious health issues. Traditional X-ray-based methods carry ra…