3 papers
stat.AP2022
Prediction of Drug-Induced TdP Risks Using Machine Learning and Rabbit Ventricular Wedge Assay
Jaela Foster-Burns, Nan Miles Xi
Torsades de pointes (TdP) is an irregular heart rhythm as a side effect of drugs and may cause sudden cardiac death. A machine learning model that can accurately identify drug TdP…
q-bio.QM2022
Prediction of Drug-Induced TdP Risks Using Machine Learning and Rabbit Ventricular Wedge Assay
Nan Miles Xi, Dalong Patrick Huang
The evaluation of drug-induced Torsades de pointes (TdP) risks is crucial in drug safety assessment. In this study, we discuss machine learning approaches in the prediction of drug…
stat.AP2021
Statistical Learning in Preclinical Drug Proarrhythmic Assessment
Nan Milex Xi, Yu-Yi Hsu, Qianyu Dang +1
Torsades de pointes (TdP) is an irregular heart rhythm characterized by faster beat rates and potentially could lead to sudden cardiac death. Much effort has been invested in under…