155 citations · 176 across the 18 of their papers we have counts for
18 papers
Dual mechanism of Anti-Seizure Medications in controlling seizure activity
Guillermo M. Besne, Emmanuel Molefi, Sarah J. Gascoigne +12
Background: Anti-seizure medications (ASMs) can reduce seizure duration, but their precise modes of action are unclear. Specifically, it is unknown whether ASMs shorten seizures by…
Status epilepticus and thinning of the entorhinal cortex
Jonathan Horsley, Yujiang Wang, Callum Simpson +6
Status epilepticus (SE) carries risks of morbidity and mortality. Experimental studies have implicated the entorhinal cortex in prolonged seizures; however, studies in large human…
The Imaging Database for Epilepsy And Surgery (IDEAS)
Peter N. Taylor, Yujiang Wang, Callum Simpson +12
Magnetic resonance imaging (MRI) is a crucial tool to identify brain abnormalities in a wide range of neurological disorders. In focal epilepsy MRI is used to identify structural c…
Anti-seizure medication tapering correlates with daytime delta band power reduction in the cortex
Guillermo M. Besne, Nathan Evans, Mariella Panagiotopoulou +11
Anti-seizure medications (ASMs) are the primary treatment for epilepsy, yet medication tapering effects have not been investigated in a dose, region, and time-dependent manner, des…
Alpha rhythm slowing in temporal epilepsy across Scalp EEG and MEG
Vytene Janiukstyte, Csaba Kozma, Thomas W. Owen +8
EEG slowing is reported in various neurological disorders including Alzheimer's, Parkinson's and Epilepsy. Here, we investigate alpha rhythm slowing in individuals with refractory…
Identifying epileptogenic abnormality by decomposing intracranial EEG and MEG power spectra
Csaba Kozma, Gabrielle Schroeder, Tom Owen +6
Identifying abnormal electroencephalographic activity is crucial in diagnosis and treatment of epilepsy. Recent studies showed that decomposing brain activity into periodic (oscill…
Diminished circadian and ultradian rhythms of human brain activity in pathological tissue in vivo
Christopher Thornton, Mariella Panagiotopoulou, Fahmida A Chowdhury +10
Chronobiological rhythms, such as the circadian rhythm, have long been linked to neurological disorders, but it is currently unknown how pathological processes affect the expressio…
Interictal MEG abnormalities to guide intracranial electrode implantation and predict surgical outcome
Thomas W. Owen, Vytene Janiukstyte, Gerard R. Hall +9
Intracranial EEG (iEEG) is the gold standard technique for epileptogenic zone (EZ) localisation, but requires a hypothesis of which tissue is epileptogenic, guided by qualitative a…
Identifying epileptogenic abnormalities through spatial clustering of MEG interictal band power
Thomas W. Owen, Vytene Janiukstyte, Gerard R. Hall +8
Successful epilepsy surgery depends on localising and resecting cerebral abnormalities and networks that generate seizures. Abnormalities, however, may be widely distributed across…
Normative brain mapping using scalp EEG and potential clinical application
Vytene Janiukstyte, Thomas W Owen, Umair J Chaudhary +6
A normative electrographic activity map could be a powerful resource to understand normal brain function and identify abnormal activity. Here, we present a normative brain map usin…
Complementary structural and functional abnormalities to localise epileptogenic tissue
Jonathan J Horsley, Rhys H Thomas, Fahmida A Chowdhury +10
When investigating suitability for surgery, people with drug-refractory focal epilepsy may have intracranial EEG (iEEG) electrodes implanted to localise seizure onset. Diffusion-we…
Temporal stability of intracranial EEG abnormality maps for localising epileptogenic tissue
Yujiang Wang, Gabrielle M Schroeder, Jonathan J Horsley +8
Objective: Identifying abnormalities in interictal intracranial EEG, by comparing patient data to a normative map, has shown promise for the localisation of epileptogenic tissue an…
Effects of anterior temporal lobe resection on cortical morphology
Karoline Leiberg, Jane de Tisi, John S Duncan +6
Anterior temporal lobe resection (ATLR) is a surgical procedure to treat drug-resistant temporal lobe epilepsy (TLE). Resection may involve large amounts of cortical tissue. Here,…
MEG abnormalities and mechanisms of surgical failure in neocortical epilepsy
Thomas W. Owen, Gabrielle M. Schroeder, Vytene Janiukstyte +8
Neocortical epilepsy surgery fails to achieve post-operative seizure freedom in 30-40% of cases. It is not fully understood why surgery in some patients is unsuccessful. Comparing…
Volumetric and structural connectivity abnormalities co-localise in TLE
Jonathan J. Horsley, Gabrielle M. Schroeder, Rhys H. Thomas +6
Patients with temporal lobe epilepsy (TLE) exhibit both volumetric and structural connectivity abnormalities relative to healthy controls. How these abnormalities inter-relate and…
Normative brain mapping of interictal intracranial EEG to localise epileptogenic tissue
Peter N Taylor, Christoforos A Papasavvas, Thomas W Owen +11
The identification of abnormal electrographic activity is important in a wide range of neurological disorders, including epilepsy for localising epileptogenic tissue. However, this…
Focal to bilateral tonic-clonic seizures are associated with widespread network abnormality in temporal lobe epilepsy
Nishant Sinha, Natalie Peternell, Gabrielle M. Schroeder +6
Objective: To identify if whole-brain structural network alterations in patients with temporal lobe epilepsy (TLE) and focal to bilateral tonic-clonic seizures (FBTCS) differ from…
The impact of epilepsy surgery on the structural connectome and its relation to outcome
Peter N Taylor, Nishant Sinha, Yujiang Wang +6
Temporal lobe surgical resection brings seizure remission in up to 80% of patients, with long-term complete seizure freedom in 41%. However, it is unclear how surgery impacts on th…