4 citations · 10 across the 8 of their papers we have counts for
7 papers · 1 filter
Clustering-Based Outcome Models for Clinical Studies: A Scoping Review
Johannes Vilsmeier, Fabian Eibensteiner, Franz König +6
This review provides a systematic overview of methods that combine covariate-based clustering of observational units (patients) with outcome models for clinical studies. We disting…
Selection Bias in Hybrid Randomized Controlled Trials using External Controls: A Simulation Study
Han Chang Chiam, Franz König, Martin Posch
Hybrid randomized controlled trials (hybrid RCTs) integrate external control data, such as historical or concurrent data, with data from randomized trials. While numerous frequenti…
Covariate adjustment for linear models in estimating treatment effects in randomised clinical trials. Some useful theory to guide simulation
Stephen Senn, Franz König, Martin Posch
Building on key papers that were published in special issues of Biometrics in 1957 and 1982 we propose and develop a three-aspect system for evaluating the effect of fitting covari…
Stratification in Randomised Clinical Trials for Rare Diseases and Analysis of Covariance: Some Simple Theory and Recommendations
Stephen Senn, Franz König, Martin Posch
A simple device for balancing for a continuous covariate in clinical trials is to stratify by whether the covariate is above or below some target value, typically the predicted med…
A two-step approach for analyzing time to event data under non-proportional hazards
Jonas Brugger, Tim Friede, Florian Klinglmüller +3
The log-rank test and the Cox proportional hazards model are commonly used to compare time-to-event data in clinical trials, as they are most powerful under proportional hazards. B…
A neutral comparison of statistical methods for time-to-event analyses under non-proportional hazards
Florian Klinglmüller, Tobias Fellinger, Franz König +10
While well-established methods for time-to-event data are available when the proportional hazards assumption holds, there is no consensus on the best inferential approach under non…
Online error control for platform trials
David S. Robertson, James M. S. Wason, Franz König +2
Platform trials evaluate multiple experimental treatments under a single master protocol, where new treatment arms are added to the trial over time. Given the multiple treatment co…