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physics.med-ph2026
Mechanistic driven TCP and NTCP modeling for particle therapy accounting for a broad range of physical irradiation parameters and tissue environmental conditions
Marco Battestini, Jules Morand, Giulio Bordieri +3
In conventional radiotherapy, the probability of controlling tumor growth is quantified using Tumor Control Probability (TCP) models. Instead, the probability of experiencing a sid…
physics.med-ph2026
A combined dose and microdosimetric modeling framework incorporating volume effects correlates with tissue sparing in proton minibeam radiotherapy
Giulio Bordieri, Marco Battestini, Gianluca Lattanzi +4
Proton minibeam (pMB) radiotherapy, delivers highly heterogeneous dose distributions alternating high-dose peaks and low-dose valleys. This aims to widen the therapeutic window by…
physics.med-ph2025
The Biologically Effective Particle Number Ratio (BPNR): a new framework to quantify the therapeutic window in SFRT and other modalities
Niels Bassler, Giuseppe Schettino, Hugo Palmans +4
Spatially Fractionated Radiation Therapy (SFRT) produces highly heterogeneous dose distributions, for which conventional metrics such as peak, valley, or average dose can yield amb…