16 citations · 36 across the 6 of their papers we have counts for
6 papers
TITE-CLRM: Towards efficient time-to-event dose-escalation guidance of multi-cycle cancer therapies
Lukas Andreas Widmer, Sebastian Weber, Yunnan Xu +1
Treatment of cancer has rapidly evolved over time in quite dramatic ways, for example from chemotherapies, targeted therapies to immunotherapies and chimeric antigen receptor T-cel…
Duration of and time to response in oncology clinical trials from the perspective of the estimand framework
Hans-Jochen Weber, Stephen Corson, Jiang Li +6
Duration of response (DOR) and time to response (TTR) are typically evaluated as secondary endpoints in early-stage clinical studies in oncology when efficacy is assessed by the be…
Quantification of follow-up time in oncology clinical trials with a time-to-event endpoint: Asking the right questions
Kaspar Rufibach, Lynda Grinsted, Jiang Li +3
For the analysis of a time-to-event endpoint in a single-arm or randomized clinical trial it is generally perceived that interpretation of a given estimate of the survival function…
The Role of Occlusion: Potential Extension of the ICH E9 (R1) Addendum on Estimands and Sensitivity Analysis for Time-to-Event Oncology Studies
Jonathan M Siegel, Hans-Jochen Weber, Stefan Englert
The ICH E9 (R1) Estimands Guidance1 terminology does not completely address the conceptual needs of time-to-event estimands in the complex oncology context. We previously described…
Time-to-event estimands and loss to follow-up in oncology in light of the estimands framework
Jonathan Siegel, Hans-Jochen Weber, Stefan Englert +1
Time-to-event estimands are central to many oncology clinical trials. The estimand framework (addendum to the ICH E9 guideline) calls for precisely defining the treatment effect of…
Estimands in Hematologic Oncology Trials
Steven Sun, Hans-Jochen Weber, Emily Butler +2
The estimand framework included in the addendum to the ICH E9 guideline facilitates discussions to ensure alignment between the key question of interest, the analysis, and interpre…