The low-entropy hydration shell at the binding site of spike RBD determines the contagiousness of SARS-CoV-2 variants

Lin Yang, Shuai Guo, Chengyu Houc +9

The infectivity of SARS-CoV-2 depends on the binding affinity of the receptor-binding domain (RBD) of the spike protein with the angiotensin converting enzyme 2 (ACE2) receptor. Th…