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Dynamic Optimization for Monoclonal Antibody Production
Morten Wahlgreen Kaysfeld, Deepak Kumar, Marcus Krogh Nielsen +1
This paper presents a dynamic optimization numerical case study for Monoclonal Antibody (mAb) production. The fermentation is conducted in a continuous perfusion reactor. We repres…
Data Assimilation for Combined Parameter and State Estimation in Stochastic Continuous-Discrete Nonlinear Systems
Tarek Diaa-Eldeen, Marcus Krogh Nielsen, Carl Fredrik Berg +2
Data assimilation (DA) provides a general framework for estimation in dynamical systems based on the concepts of Bayesian inference. This constitutes a common basis for the differe…
Modelling and Economic Optimal Control for a Laboratory-scale Continuous Stirred Tank Reactor for Single-cell Protein Production
Marcus Krogh Nielsen, Jens Dynesen, Jess Dragheim +5
In this paper, we present a novel kinetic growth model for the micro-organism \textit{Methylococcus capsulatus} (Bath) that couples growth and pH. We apply growth kinetics in a mod…
State Estimation for Continuous-Discrete-Time Nonlinear Stochastic Systems
Marcus Krogh Nielsen, Tobias K. S. Ritschel, Ib Christensen +4
State estimation incorporates the feedback in optimization based advanced process control systems and is very important for the performance of model predictive control. We describe…
State Estimation Methods for Continuous-Discrete Nonlinear Systems involving Stochastic Differential Equations
Marcus Krogh Nielsen, Tobias K. S. Ritschel, Ib Christensen +4
In this work, we present methods for state estimation in continuous-discrete nonlinear systems involving stochastic differential equations. We present the extended Kalman filter, t…