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q-bio.CB2026
Fragmented uptake drives lipid accumulation in macrophage cannibalistic efferocytosis
Keith L. Chambers
Efferocytosis, the clearance of dying cells typically by macrophages, is essential for tissue homeostasis and the resolution of inflammation. Previous experiments by Ford et al. (P…
q-bio.CB2026
A quantitative model for the emergent population dynamics of the melanoma MITF rheostat
Keith L. Chambers, Richard M. White, Colin R. Goding +1
Cancer progression is driven by the ability of cells with identical driver mutations to adopt biologically distinct adaptive phenotypes. Yet the population dynamics implied by intr…
q-bio.PE2026
A multiscale discrete-to-continuum framework for structured population models
Eleonora Agostinelli, Keith L. Chambers, Helen M. Byrne +1
Mathematical models of biological populations commonly use discrete structure classes to capture trait variation among individuals (e.g. age, size, phenotype, intracellular state).…