5 papers · 1 filter
Fragmented uptake drives lipid accumulation in macrophage cannibalistic efferocytosis
Keith L. Chambers
Efferocytosis, the clearance of dying cells typically by macrophages, is essential for tissue homeostasis and the resolution of inflammation. Previous experiments by Ford et al. (P…
A quantitative model for the emergent population dynamics of the melanoma MITF rheostat
Keith L. Chambers, Richard M. White, Colin R. Goding +1
Cancer progression is driven by the ability of cells with identical driver mutations to adopt biologically distinct adaptive phenotypes. Yet the population dynamics implied by intr…
A spatially resolved and lipid-structured model for macrophage populations in early human atherosclerotic lesions
Keith L. Chambers, Mary R. Myerscough, Michael G. Watson +1
Atherosclerosis is a chronic inflammatory disease of the artery wall. The early stages of atherosclerosis are driven by interactions between lipids and monocyte-derived-macrophages…
Blood lipoproteins shape the phenotype and lipid content of early atherosclerotic lesion macrophages: a dual-structured mathematical model
Keith L Chambers, Mary R Myerscough, Michael G Watson +1
Macrophages in atherosclerotic lesions exhibit a spectrum of behaviours or phenotypes. The phenotypic distribution of monocyte-derived macrophages (MDMs), its correlation with MDM…
A Lipid-Structured Model of Atherosclerotic Plaque Macrophages with Lipid-Dependent Kinetics
M. G. Watson, K. L. Chambers, M. R. Myerscough
Atherosclerotic plaques are fatty growths in artery walls that cause heart attacks and strokes. Plaque formation is orchestrated by macrophages that are recruited to the artery wal…