most citedPredicting Cellular Responses to Novel Drug Perturbations at a Single-Cell Resolution

44 citations · 84 across the 10 of their papers we have counts for

collaborators

10 papers

cs.CV2023★ 4 cited

Unbalancedness in Neural Monge Maps Improves Unpaired Domain Translation

Luca Eyring, Dominik Klein, Théo Uscidda +4

In optimal transport (OT), a Monge map is known as a mapping that transports a source distribution to a target distribution in the most cost-efficient way. Recently, multiple neura…

stat.ML2023

GENOT: Entropic (Gromov) Wasserstein Flow Matching with Applications to Single-Cell Genomics

Dominik Klein, Théo Uscidda, Fabian Theis +1

Single-cell genomics has significantly advanced our understanding of cellular behavior, catalyzing innovations in treatments and precision medicine. However, single-cell sequencing…

cs.LG2023★ 8 cited

Conditionally Invariant Representation Learning for Disentangling Cellular Heterogeneity

Hananeh Aliee, Ferdinand Kapl, Soroor Hediyeh-Zadeh +1

This paper presents a novel approach that leverages domain variability to learn representations that are conditionally invariant to unwanted variability or distractors. Our approac…

cs.LG2023

The power of motifs as inductive bias for learning molecular distributions

Johanna Sommer, Leon Hetzel, David Lüdke +2

Machine learning for molecules holds great potential for efficiently exploring the vast chemical space and thus streamlining the drug discovery process by facilitating the design o…

physics.chem-ph2023★ 1 cited

MAGNet: Motif-Agnostic Generation of Molecules from Shapes

Leon Hetzel, Johanna Sommer, Bastian Rieck +2

Recent advances in machine learning for molecules exhibit great potential for facilitating drug discovery from in silico predictions. Most models for molecule generation rely on th…

cs.AI2023

Training Transitive and Commutative Multimodal Transformers with LoReTTa

Manuel Tran, Yashin Dicente Cid, Amal Lahiani +3

Training multimodal foundation models is challenging due to the limited availability of multimodal datasets. While many public datasets pair images with text, few combine images wi…

q-bio.GN2022★ 5 cited

Uncertainty Quantification for Atlas-Level Cell Type Transfer

Jan Engelmann, Leon Hetzel, Giovanni Palla +3

Single-cell reference atlases are large-scale, cell-level maps that capture cellular heterogeneity within an organ using single cell genomics. Given their size and cellular diversi…

cs.LG2022★ 6 cited

Sparsity in Continuous-Depth Neural Networks

Hananeh Aliee, Till Richter, Mikhail Solonin +3

Neural Ordinary Differential Equations (NODEs) have proven successful in learning dynamical systems in terms of accurately recovering the observed trajectories. While different typ…

eess.IV2022★ 16 cited

FedNorm: Modality-Based Normalization in Federated Learning for Multi-Modal Liver Segmentation

Tobias Bernecker, Annette Peters, Christopher L. Schlett +5

Given the high incidence and effective treatment options for liver diseases, they are of great socioeconomic importance. One of the most common methods for analyzing CT and MRI ima…

cs.LG2022★ 44 cited

Predicting Cellular Responses to Novel Drug Perturbations at a Single-Cell Resolution

Leon Hetzel, Simon Böhm, Niki Kilbertus +3

Single-cell transcriptomics enabled the study of cellular heterogeneity in response to perturbations at the resolution of individual cells. However, scaling high-throughput screens…