4 papers
Fluctuation-Response Theory of Non-Equilibrium Complex Fluids
Ryota Takaki, Frank Jülicher
A fundamental challenge in soft matter physics is to describe materials, such as the living cytoplasm and tissues, that are simultaneously active, chemically driven, and exhibit lo…
Loop Extrusion Reversal by Condensin Motor is Mediated by Catch Bonds
Atreya Dey, Guang Shi, Ryota Takaki +1
Structural Maintenance Complexes (SMC) are energy consuming motors that are important in folding the genome by loop extrusion (LE) in all stages of the cell cycle. Single molecule…
Active Loop Extrusion guides DNA-Protein Condensation
Ryota Takaki, Yahor Savich, Jan Brugués +1
The spatial organization of DNA involves DNA loop extrusion and the formation of protein-DNA condensates. While the significance of each process is increasingly recognized, their i…
Sequence Complexity and Monomer Rigidity Control the Morphologies and Aging Dynamics of Protein Aggregates
Ryota Takaki, Dave Thirumalai
Protein aggregates exhibit diverse morphology, exemplified by amyloid fibrils, gel-like structures, and liquid-like condensates. Differences in the morphologies in identical protei…