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q-bio.QM2026
Identifiability Limits of Physics-Informed Inference for Spatial Stochastic Dynamics from Static Snapshots
Rujie Gu, Ray Zirui Zhang, Christopher E. Miles
Despite increasing scale and resolution, many biological measurements remain destructive, revealing only spatial information rather than the dynamics it encodes. By combining flexi…
q-bio.QM2025
Mechanistic inference of stochastic gene expression from structured single-cell data
Christopher E. Miles
Single-cell gene expression measurements encode variability spanning molecular noise, cell-to-cell heterogeneity, and technical artifacts. Mechanistic stochastic models provide pow…