3 papers
q-bio.CB2026
GlycoMAC: A Multiscale Metabolic-Glycosylation Framework for Predicting Glycosylation Across Conditions in Mammalian Cell Cultures
Yuming Zeng, Sarah W. Harcum, Jinxiang Pei +1
Antibody productivity and glycosylation quality in CHO cultures arise from a dynamically evolving metabolic environment, yet models often work in isolation or at a single scale. He…
q-bio.CB2026
Intracellular Measurement-Informed Multiscale Modeling for Scalable iPSC Manufacturing
Fuqiang Cheng, Zahra Foroozan Jahromi, Keqi Wang +10
Scalable manufacturing of human induced pluripotent stem cells (iPSCs) is essential for industrial-scale production of cell therapies and regenerative medicines. However, the 3D ag…
q-bio.MN2025
Multi-Scale Hybrid Modeling to Predict Cell Culture Process with Metabolic Phase Transitions
Keqi Wang, Sarah W. Harcum, Wei Xie
To advance understanding of cellular metabolism and reduce batch-to-batch variability in cell culture processes, this study introduces a multi-scale hybrid modeling framework desig…