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1 paper

stat.ME2024

ROMI: A Randomized Two-Stage Basket Trial Design to Optimize Doses for Multiple Indications

Shuqi Wang, Peter F. Thall, Kentaro Takeda +1

Optimizing doses for multiple indications is challenging. The pooled approach of finding a single optimal biological dose (OBD) for all indications ignores that dose-response or do…