14 papers
Value-of-Information Analysis for External Validation of Risk Prediction Models in Multicenter Studies and Systematic Reviews
Laure Wynants, Kim Zhipei Wang, Sabine Grimm +5
External validation studies have finite sample sizes, creating uncertainty about whether a prediction model's Net Benefit (NB) exceeds default strategies' NB. The expected value of…
Progression to the mean: A comparison of Bayesian clinical prediction models outputting the posterior mean versus conventional plug-in predictions
Mohsen Sadatsafavi, Richard D. Riley
Clinical prediction models provide predictions for individuals, typically expressed as point estimates derived from a deterministic function, such as a logistic regression equation…
What Medicine Taught Us About Fairness and What It Missed: Lessons from Reconsidering Race-Specific Lung Function Reference Algorithms
Amin Adibi, Mohsen Sadatsafavi
Since 2019, medical societies have reconsidered race-specific clinical equations often in parallel to and largely independent from algorithmic fairness research. Focusing on lung f…
Non-parametric assessment of the calibration of individualized treatment effects
Mohsen Sadatsafavi, Jeroen Hoogland, Thomas P. A. Debray +1
An important aspect of the performance of algorithms that predict individualized treatment effects (ITE) is moderate calibration, i.e., the average treatment effect among individua…
Transportability of Prognostic Markers: Rethinking Common Practices through a Sufficient-Component-Cause Perspective
Mohsen Sadatsafavi, Gavin Pereira, Wenjia Chen
Transportability, the ability to maintain performance across populations, is a desirable property of markers of clinical outcomes. However, empirical findings indicate that markers…
Evaluating Treatment Benefit Predictors using Observational Data: Contending with Identification and Confounding Bias
Yuan Xia, Mohsen Sadatsafavi, Paul Gustafson
A treatment benefit predictor (TBP) is a function that maps patient characteristics to an estimate of the treatment benefit for that patient. Such predictors support optimizing ind…