3 papers
cs.LG2026
Multipath Adaptive Gated Bottleneck Latent ODE with Raman Data Fusion for Cell Culture Process Forecasting
Johnny Peng, Thanh Tung Khuat, Ellen Otte +2
Mammalian cell-culture processes underpin the manufacture of many biopharmaceuticals, yet keeping a run on track is hard: critical process parameters drift over days, and an off-sp…
q-bio.QM2025
Learning From Limited Data and Feedback for Cell Culture Process Monitoring: A Comparative Study
Johnny Peng, Thanh Tung Khuat, Ellen Otte +2
In cell culture bioprocessing, real-time batch process monitoring (BPM) refers to the continuous tracking and analysis of key process variables such as viable cell density, nutrien…
q-bio.QM2025
Lessons Learned from Deploying Adaptive Machine Learning Agents with Limited Data for Real-time Cell Culture Process Monitoring
Thanh Tung Khuat, Johnny Peng, Robert Bassett +2
This study explores the deployment of three machine learning (ML) approaches for real-time prediction of glucose, lactate, and ammonium concentrations in cell culture processes, us…