10 citations · 20 across the 10 of their papers we have counts for
10 papers
Drug release dynamics from a three-layer composite contact lens in the vial, eye wear with blinking, and blister pack settings
Daniel M. Anderson, Rayanne A. Luke
In this work we design a multi-layer model of composite contact lens drug release. Such lenses have been designed by encapsulating drug-polymer films in contact lens hydrogels. Com…
A geometry-dependent, force balance-driven model of Staphylococcus epidermidis biofilm cell cluster detachment
Yuehui Xu, Jasmine A. F. Kreig, Zhuoran Wang +3
Biofilms, bacteria cells surrounded by a self-produced polymeric matrix, are common on medical devices and lead to many hospital infections. The biofilm lifecycle includes disassem…
Probabilistic Modeling of Antibody Kinetics Post Infection and Vaccination: A Markov Chain Approach
Rayanne A. Luke, Prajakta Bedekar, Lyndsey M. Muehling +7
Understanding the dynamics of antibody levels is crucial for characterizing the time-dependent response to immune events: either infections or vaccinations. The sequence and timing…
Prevalence estimation methods for time-dependent antibody kinetics of infected and vaccinated individuals: a graph-theoretic approach
Prajakta Bedekar, Rayanne A. Luke, Anthony J. Kearsley
Immune events such as infection, vaccination, and a combination of the two result in distinct time-dependent antibody responses in affected individuals. These responses and event p…
Mathematical models of drug delivery via a contact lens during wear
Daniel M. Anderson, Rayanne A. Luke
In this work we develop and investigate mathematical and computational models that describe drug delivery from a contact lens during wear. Our models are designed to predict the dy…
Optimal classification and generalized prevalence estimates for diagnostic settings with more than two classes
Rayanne A. Luke, Anthony J. Kearsley, Paul N. Patrone
An accurate multiclass classification strategy is crucial to interpreting antibody tests. However, traditional methods based on confidence intervals or receiver operating character…
Fitting ODE models of tear film breakup
Tobin A. Driscoll, Richard J. Braun, Rayanne A. Luke +5
The contribution of different physical effects to tear breakup (TBU) in subjects with no self-reported history of dry eye are quantified. An automated system using a convolutional…
Modeling in higher dimensions to improve diagnostic testing accuracy: theory and examples for multiplex saliva-based SARS-CoV-2 antibody assays
Rayanne A. Luke, Anthony J. Kearsley, Nora Pisanic +4
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has emphasized the importance and challenges of correctly interpreting antibody test results. Identificati…
Mechanistic determination of tear film thinning via fitting simplified models to tear breakup
Rayanne A. Luke, Richard J. Braun, Carolyn G. Begley
Purpose: To determine whether evaporation, tangential flow, or a combination of the two cause tear film breakup in a variety of instances; to estimate related breakup parameters th…
Parameter Estimation for Mixed-Mechanism Tear Film Thinning
Rayanne A. Luke, Richard J. Braun, Tobin A. Driscoll +2
Etiologies of tear breakup include evaporation-driven, divergent flow-driven, and a combination of these two. A mathematical model incorporating evaporation and lipid-driven tangen…