The effects of beta-cell mass and function, intercellular coupling, and islet synchrony on ${\text{Ca}}^{2+}$ dynamics

Maryam Saadati, Yousef Jamali

Type 2 diabetes (T2D) is a challenging metabolic disorder characterized by a substantial loss of $\beta$-cell mass and alteration of $\beta$-cell function in the islets of Langerhans, disr…