2 papers
q-bio.QM2022
Integrating molecular models into CryoEM heterogeneity analysis using scalable high-resolution deep Gaussian mixture models
Muyuan Chen, Bogdan Toader, Roy Lederman
Resolving the structural variability of proteins is often key to understanding the structure-function relationship of those macromolecular machines. Single particle analysis using…
q-bio.BM2021
Deep learning based mixed-dimensional GMM for characterizing variability in CryoEM
Muyuan Chen, Steven Ludtke
Structural flexibility and/or dynamic interactions with other molecules is a critical aspect of protein function. CryoEM provides direct visualization of individual macromolecules…