2 papers
stat.ME2022
Stratified modestly-weighted log-rank tests in settings with an anticipated delayed separation of survival curves
Dominic Magirr, José L. Jiménez
Delayed separation of survival curves is a common occurrence in confirmatory studies in immuno-oncology. Many novel statistical methods that aim to efficiently capture potential lo…
stat.AP2021
Design and Analysis of group-sequential clinical trials based on a modestly-weighted log-rank test in anticipation of a delayed separation of survival curves: A practical guidance
Dominic Magirr, José L. Jiménez
A common feature of many recent trials evaluating the effects of immunotherapy on survival is that non-proportional hazards can be anticipated at the design stage. This raises the…