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20212025
most citedPossible Contexts of Use for In Silico trials methodologies: a consensus-based review

64 citations · 64 across the 6 of their papers we have counts for

collaborators

6 papers

cs.LG2025

Machine Learning Framework for Thrombosis Risk Prediction in Rotary Blood Pumps

Christopher Blum, Michael Neidlin

Thrombosis in rotary blood pumps arises from complex flow conditions that remain difficult to translate into reliable and interpretable risk predictions using existing computationa…

physics.med-ph2025

Bayesian Parameter Inference and Uncertainty-Informed Sensitivity Analysis in a 0D Cardiovascular Model for Intraoperative Hypotension

Jan-Niklas Thiel, Marko Zlicar, Ulrich Steinseifer +2

Computational cardiovascular models are promising tools for clinical decision support, particularly in complex conditions, such as intraoperative hypotension (IOH). IOH arises from…

physics.flu-dyn2025

Characterizing Intraventricular Flow Patterns via Modal Decomposition Techniques in Idealized Left Ventricle Models

Eneko Lazpita, Michael Neidlin, Jesus Garicano-Mena +1

Understanding the formation, propagation, and breakdown of the main vortex ring (VR) is essential for characterizing left ventricular (LV) hemodynamics, as its dynamics have been l…

physics.med-ph2024

Towards Robust Hemolysis Modeling with Uncertainty Quantification: A Universal Approach to Address Experimental Variance

Christopher Blum, Ulrich Steinseifer, Michael Neidlin

Purpose: The purpose of this study is to address the lack of uncertainty quantification in numerical hemolysis models, which are critical for medical device evaluations. Specifical…

physics.med-ph2024

Quantifying the Influence of Combined Lung and Kidney Support Using a Cardiovascular Model and Sensitivity Analysis-Informed Parameter Identification

Jan-Niklas Thiel, Ana Martins Costa, Bettina Wiegmann +3

Combined extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT) pose complex hemodynamic challenges in intensive care. In this study, a comprehe…

physics.bio-ph2021★ 64 cited

Possible Contexts of Use for In Silico trials methodologies: a consensus-based review

Marco Viceconti, Luca Emili, Payman Afshari +15

The term "In Silico Trial" indicates the use of computer modelling and simulation to evaluate the safety and efficacy of a medical product, whether a drug, a medical device, a diag…