5 papers
Spectral Rewiring for Exploration, Purification, and Model Merging
Zhilong Zhang, Hongli Yu, Huan-ang Gao +5
Reinforcement learning has become a standard post-training recipe for large language models, but dense full-parameter updates create two deployment-relevant bottlenecks: suppressed…
Demystifying Multimodal Biomolecular Co-design With Intrinsic Geodesic Coupling
Keyue Qiu, Xintong Wang, Zhilong Zhang +2
Biomolecules such as proteins and small-molecule ligands play a central role in biological systems, arising from the tight interplay between sequence and three-dimensional structur…
Empower Structure-Based Molecule Optimization with Gradient Guided Bayesian Flow Networks
Keyue Qiu, Yuxuan Song, Jie Yu +7
Structure-Based molecule optimization (SBMO) aims to optimize molecules with both continuous coordinates and discrete types against protein targets. A promising direction is to exe…
Consistency Flow Matching: Defining Straight Flows with Velocity Consistency
Ling Yang, Zixiang Zhang, Zhilong Zhang +6
Flow matching (FM) is a general framework for defining probability paths via Ordinary Differential Equations (ODEs) to transform between noise and data samples. Recent approaches a…
Contextualized Diffusion Models for Text-Guided Image and Video Generation
Ling Yang, Zhilong Zhang, Zhaochen Yu +4
Conditional diffusion models have exhibited superior performance in high-fidelity text-guided visual generation and editing. Nevertheless, prevailing text-guided visual diffusion m…