2 citations · 3 across the 3 of their papers we have counts for
3 papers
Stochastic modelling reveals that chromatin folding buffers epigenetic landscapes against sirtuin depletion during DNA damage
Daria Stepanova, Helen M. Byrne, Tomás Alarcón
Epigenetic landscapes, represented by patterns of chemical modifications on histone tails, are essential for maintaining cell identity and tissue homeostasis. These landscapes are…
Understanding how chromatin folding and enzyme competition affect rugged epigenetic landscapes
Daria Stepanova, Meritxell Brunet Guasch, Helen M. Byrne +1
Epigenetics plays a key role in cellular differentiation and maintaining cell identity, enabling cells to regulate their genetic activity without altering the DNA sequence. Epigene…
A method to coarse-grain multi-agent stochastic systems with regions of multistability
Daria Stepanova, Helen M. Byrne, Philip K. Maini +1
Hybrid multiscale modelling has emerged as a useful framework for modelling complex biological phenomena. However, when accounting for stochasticity in the internal dynamics of age…