2 papers
stat.ME2021
An Empirical Bayes Robust Meta-Analytical-Predictive Prior to Adaptively Leverage External Data
Hongtao Zhang, Yueqi Shen, Alan Y Chiang +1
We propose a novel empirical Bayes robust MAP (EB-rMAP) prior to adaptively leverage external/historical data. Built on Box's prior predictive p-value, the EB-rMAP prior framework…
stat.ME2021
Improving the Performance of Bayesian Logistic Regression Model with Overdose Control in Oncology Dose-Finding Studies
Hongtao Zhang, Alan Y Chiang, Jixian Wang
An accurately identified maximum tolerated dose (MTD) serves as the cornerstone of successful subsequent phases in oncology drug development. Bayesian logistic regression model (BL…