14 citations · 56 across the 9 of their papers we have counts for
10 papers
A meta-algorithm for ab initio reconstruction of complex mixtures in cryo-EM
Alkin Kaz, Arda Kaz, Ellen D. Zhong
We describe a systematic approach for spawning and aggregating multi-class cryo-EM reconstruction jobs. This approach formalizes standard ad hoc strategies of iterative classificat…
Atomic Diffusion Models for Small Molecule Structure Elucidation from NMR Spectra
Ziyu Xiong, Yichi Zhang, Foyez Alauddin +4
Nuclear Magnetic Resonance (NMR) spectroscopy is a cornerstone technique for determining the structures of small molecules and is especially critical in the discovery of novel natu…
CryoHype: Reconstructing a thousand cryo-EM structures with transformer-based hypernetworks
Jeffrey Gu, Minkyu Jeon, Ambri Ma +2
Cryo-electron microscopy (cryo-EM) is an indispensable technique for determining the 3D structures of dynamic biomolecular complexes. While typically applied to image a single mole…
Multiscale guidance of protein structure prediction with heterogeneous cryo-EM data
Rishwanth Raghu, Axel Levy, Gordon Wetzstein +1
Protein structure prediction models are now capable of generating accurate 3D structural hypotheses from sequence alone. However, they routinely fail to capture the conformational…
Mixture of neural fields for heterogeneous reconstruction in cryo-EM
Axel Levy, Rishwanth Raghu, David Shustin +5
Cryo-electron microscopy (cryo-EM) is an experimental technique for protein structure determination that images an ensemble of macromolecules in near-physiological contexts. While…
CryoBench: Diverse and challenging datasets for the heterogeneity problem in cryo-EM
Minkyu Jeon, Rishwanth Raghu, Miro Astore +6
Cryo-electron microscopy (cryo-EM) is a powerful technique for determining high-resolution 3D biomolecular structures from imaging data. Its unique ability to capture structural va…
Solving Inverse Problems in Protein Space Using Diffusion-Based Priors
Axel Levy, Eric R. Chan, Sara Fridovich-Keil +3
The interaction of a protein with its environment can be understood and controlled via its 3D structure. Experimental methods for protein structure determination, such as X-ray cry…
Latent Space Diffusion Models of Cryo-EM Structures
Karsten Kreis, Tim Dockhorn, Zihao Li +1
Cryo-electron microscopy (cryo-EM) is unique among tools in structural biology in its ability to image large, dynamic protein complexes. Key to this ability is image processing alg…
Amortized Inference for Heterogeneous Reconstruction in Cryo-EM
Axel Levy, Gordon Wetzstein, Julien Martel +2
Cryo-electron microscopy (cryo-EM) is an imaging modality that provides unique insights into the dynamics of proteins and other building blocks of life. The algorithmic challenge o…
Exploring generative atomic models in cryo-EM reconstruction
Ellen D. Zhong, Adam Lerer, Joseph H. Davis +1
Cryo-EM reconstruction algorithms seek to determine a molecule's 3D density map from a series of noisy, unlabeled 2D projection images captured with an electron microscope. Althoug…