101 citations · 319 across the 9 of their papers we have counts for
9 papers
Compact assessment of molecular surface complementarities enhances neural network-aided prediction of key binding residues
Greta Grassmann, Lorenzo Di Rienzo, Giancarlo Ruocco +2
Predicting interactions between biomolecules, such as protein-protein complexes, remains a challenging problem. Despite the many advancements done so far, the performances of docki…
Zepyros: A webserver to evaluate the shape complementarity of protein-protein interfaces
Mattia Miotto, Lorenzo Di Rienzo, Leonardo Bo' +2
Shape complementarity of molecular surfaces at the interfaces is a well-known characteristic of protein-protein binding regions, and it is critical in influencing the stability of…
Electrostatic complementarity at the interface drives transient protein-protein interactions
Greta Grassmann, Lorenzo Di Rienzo, Giorgio Gosti +4
Understanding the molecular mechanisms driving the binding between bio-molecules is a crucial challenge in molecular biology. In this respect, characteristics like the preferential…
Investigating the side-chain structural organization behind the stability of protein folding and binding
Fausta Desantis, Mattia Miotto, Lorenzo Di Rienzo +2
What are the molecular mechanisms that dictate protein-protein binding stability and whether those are related to the ones behind protein fold stability are still largely open ques…
New algorithm to determine a minimal representation of the molecular surface
Greta Grassmann, Mattia Miotto, Lorenzo Di Rienzo +3
Most proteins perform their biological function by interacting with one or more molecular partners. In this respect, characterizing the features of the molecular surface, especiall…
Shape Complementarity Optimization of Antibody-Antigen Interfaces: the Application to SARS-CoV-2 Spike Protein
Alfredo De Lauro, Lorenzo Di Rienzo, Mattia Miotto +3
Many factors influence biomolecules binding, and its assessment constitutes an elusive challenge in computational structural biology. In this respect, the evaluation of shape compl…
Molecular mechanisms behind anti SARS-CoV-2 action of lactoferrin
Mattia Miotto, Lorenzo Di Rienzo, Leonardo Bò +3
Despite the huge effort to contain the infection, the novel SARS-CoV-2 coronavirus has rapidly become pandemics, mainly due to its extremely high human-to-human transmission capabi…
Does blood type affect the COVID-19 infection pattern?
Mattia Miotto, Lorenzo Di Rienzo, Giorgio Gosti +2
Among the many aspects that characterize the COVID-19 pandemic, two seem particularly challenging to understand: (i) the great geographical differences in the degree of virus conta…
In-Silico evidence for two receptors based strategy of SARS-CoV-2
Edoardo Milanetti, Mattia Miotto, Lorenzo Di Rienzo +3
We propose a novel numerical method able to determine efficiently and effectively the relationship of complementarity between portions of proteins surfaces. This innovative and gen…